The Yellow Submarine, who were seeded in Pot One, were drawn with Israeli side Maccabi Tel Aviv, Astana of Kazakhstan – who crashed out of the Champions League against Glasgow Celtic – and Slavia Prague.
Athletic Club, also seeded following their playoff victory over Panathinaikos, will face Hertha Berlin, Ukrainian side Zorya and Swedish team Ostersunds.
La Real were seeded in pot two and their top seeded team to face are Russian giants Zenit Saint Petersburg, along with games Norwegian outfit Rosenborg and Vardar of Macedonia.
The group stages of the Europa League will begin on September 14 and the tournament victors will earn a place in the Champions League.
Europa League Groups
GROUP A: Villarreal (Spain), Maccabi Tel-Aviv (Israel), Astana (Kazakhstan), Slavia Praha (Czech Republic)
GROUP B: Dynamo Kyiv (Ukraine), Young Boys (Switzerland), Partizan (Serbia), Skenderbeu (Albania)
GROUP C: Sporting Braga (Portugal), Ludogorets (Bulgaria), Hoffenheim (Germany), Istanbul Basaksehir (Turkey)
GROUP D: AC Milan (Italy), Austria Vienna (Austria), Rijeka (Croatia), AEK Athens (Greece)
GROUP E: Lyon (France), Everton (England), Atalanta (Italy), Apollon (Cyprus)
GROUP F: Copenhagen (DEN), Lokomotiv Moscow (RUS), Sheriff (MDA), Zlin (Czech Republic)
GROUP G: Victoria Plzen (Czech Republic), Steaua Bucharest (Romanian), Hapoel Beer-Sheva (Isreal), Lugano (Switzerland)
GROUP H: Arsenal (England), BATE Borisov (Bulgaria) Cologne (Germany), Red Star Belgrade (Serbia)
GROUP I: Salzburg (Austria) Marseille (France) Vitoria SC (Portugal) Konyaspor (Turkey)
GROUP J: Athletic Bilbao (Spain), Hertha Berlin (Germany), Zorya (Ukraine), Ostersund (Sweden)
GROUP K: Lazio (Italy), Nice (France), Zulte Waregem (Belgium), Vitesse (Holland)
GROUP L: Zenit St Petersberg (Russia), Real Sociedad (Spain), Rosenborg (Norway), Vardar (Macedonia)