Los Che are among the tournament favourites having knocked out Celtic and Krasnodar to reach the last eight of the competition and will face Villarreal, who lie 60km from their home city.
The Yellow Submarine are struggling in La Liga this season – sitting just one place outside the relegation zone – but have shown impressive form in Europe.
They have eliminated both Sporting CP and Zenit Saint Petersburg and will be hoping for their second Europa League semi-final spot in the space of four years.
Maurizio Sarri’s side, who are still unbeaten in this season’s competition, were awarded a favourable tie against Slavia Prague while Benfica and Frankfurt will go head to head for a place in the semi-finals of the competition.
The winners of the all-Spanish tie will face the winners of Napoli against Arsenal in the last four of the competition.
The first legs will be played on 11 April, and the second legs will be played on 18 April 2019.
Europa League Quarter Final First Leg
Napoli vs Arsenal – Buy Europa League Tickets
Villarreal vs Valencia – Buy Europa League Tickets
Benfica vs Frankfurt – Buy Europa League Tickets
Slavia Prague vs Chelsea – Buy Europa League Tickets
Europa League Quarter Final Second Leg
Arsenal vs Napoli – Buy Europa League Tickets
Valencia vs Villarreal – Buy Europa League Tickets
Frankfurt vs Benfica – Buy Europa League Tickets
Chelsea vs Slavia Prague – Buy Europa League Tickets